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Friday, April 26, 2013

RHYTHMS IN HUMAN BODY

                    RHYTHMS IN HUMAN BODY

                              
What is rhythm?

Rhythm simply means repetition of a feature. If we analyze we will know that everything in this universe has rhythm. Be it music or dance or other entities of universe they all have rhythm. If we observe our daily life it too has rhythm. Even matter which appears still is vibrating in its own rhythm. Matter is composed of energy and can be annihilated into energy and this energy is simply rhythms and therefore it can be concluded that everything is rhythm. Since it is a medical magazine here we are going to discuss rhythm in context of some very interesting features of human body.


 INTRODUCTION TO RHYTHMS OF HUMAN BODY:

"Although it may not be apparent to a layperson, the human body is largely run by “biological rhythms.” All organs, systems and cells are controlled by exact, cyclic patterns of rest and activity, which we can aptly call the “universal laws of life.” ", Andreas Moritz in naturalnews.com

There are activities in our body which happen rhythmically (that happens in only certain time of day and repeats itself in a particular pattern). we observe some of them, some of them are observed but not analyzed and some of them are observed only through detail studies of human body and not observable by general population.

       Few Examples of such activities
      
GENERALLY OBSERVED FACTS
        1.)1. Body temperature is lowest before waking up in the morning, and highest in the late afternoon.

        2.) The large bowel is most active and efficient during the early morning hours i.e. the urge to purge is most during early morning than other time of day.
        3.) Births peak in the morning and early afternoon and so do suicides.
        4.) People have sexual urge more at night just before going to bed than other any time of the day.
        5.) If we have a very good routine we will observe that we do same type of thing at same time of day and generally have same type of mood at same time.

FACTS OBSERVABLE ONLY BY DETAILED STUDIES
        1.) Doctors often prescribe taking medicines at certain times of day. This is because  drugs give more efficacy and minimum toxicity at particular time.  
        2.)The liver is more active during the night than it is during the day.
        3.)Red bone marrow produces more blood cells during the night.
        4.)Most digestive enzymes are secreted during the day.
        5.)Different types of cells have different life spans and are turned over at specific intervals.
       6.) Bile secretions peak at midday.


Apart from the fact mentioned above there are many other activities that occurs rhythmically.
so what is responsible for maintaining this rhythm in our body ?


CAUSE OF BIOLOGICAL RHYTHM 


CIRCADIAN RHYTHM "A circadian rhythm is any biological process that displays an endogenous, entrainable oscillation of about 24 hours. ", wikipedia

The rhythm is not only observed in humans but widely in many plants, animals and microorganisms. A circadian rhythm is built in and adjustable to environment.

FOUR CRITERIA OF BIOLOGICAL RHYTHM TO BECOME CIRCADIAN RHYTHM
1.)The rhythms repeat once a day.
2.)The rhythms persist in the absence of external cues.
3.)The rhythms can be adjusted to match the local time.
4.)The rhythms maintain circadian periodicity over a range of physiological temperatures; they exhibit temperature compensation. 
     
  

 




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Saturday, March 31, 2012

PERNICOUS ANAEMIA- TYPE OF MEGALOBLASTIC ANAEMIA


                                            PERNICIOUS ANAEMIA


Pernicious anaemia is a type of megaloblastic anaemia due inablity to secrete intrinsic factor that helps in absorption of vitamin B12.
                                                        PERNICIOUS ANAEMIA 
                                                        BLOOD PICTURE


      a.) WHAT CAUSES PERNICIOUS ANAEMIA ?
      ans:->Pernicious anaemia occurs as a complication of rheumatoid gastritis.
                                                    GROSS: RHEUMATOID GASTRITIS

Rheumatoid gastritis leads to damage of parietal  cell of fundic mucousa which is responsible for     secretion of intrinsic factor. Therefore depletion of parietal cells leads to lack of intrinsic factor.           Intrinsic factor is responsible for absorption of vitamin B12 . So lack of intrinsic factor leads to             anaemia.
   
     

  b.) WHAT DOES THE WORD PERNICIOUS MEAN ? 
      ans:-> The word 'PERNICIOUS' means 'DESTRUCTIVE'In medical term it is used to denote               diseaseof severe charracter and usually fatal without appropriate treatment.  

since there is no treatment or cure for pernicious anaemia after it's clinical signs are seen and
since it is a very severe type of megaloblastic anaemia the term pernicious is appropriate.



  c.) CAN ALL CASES OF VITAMIN B12 DEFICIENCY BE                              CALLED PERNICIOUS ANAEMIA ? 
    ans:-> NO
Only the vitamin B12 deficiency due to deficieny of intrinsic factor can be called as pernicious anaemia.


  d.) WHY DOES VITAMIN B12 DEFICIENCY LEAD TO                                  ANAEMIA ?
     ans:-> Vitamin B12 is important factor for DNA synthesis during erythropoesis. Deficiency of vitamin B12 leads to impairment of DNA synthesis that leads to distinctive morphologicchanges and abnormally large erythroid precursors and red cells which are inappropriate for normal RBC function and there fore leads to anaemia.
The large erythroid precusrsors are called megaloblasts and therefore the anaemia is called           megaloblastic anaemia
                                    MEGALOBLASTS SURROUNDED BY GAINT BANDS
      
     


       e.) ARE ALL MEGALOBLASTIC ANAEMIA CAUSED                                  ONLY DUE TO FOLATE DEFICIENCY ?    
         ans:-> NO. Megaloblastic naaemia can be either due to folate deficiency or vitamin B12                          deficiency.

 PERNICIOUS ANAEMIA IS DUE TO FOLATE DEFICIENCY.          


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Friday, March 30, 2012

PAST AND FUTURE OF MEDICINE

MEDS TMIELINE



1500 BC         HERE TAKE THIS HERB
1000 BC         THAT HERB IS HEATHEN, DRINK THIS POTION
100   AD         THAT POTION IS SMOKE OIL, SAY THIS PRAYER
2000 AD         PRAYER DON'T WORK,TAKE THIS PILL
2015 AD         PILLS DON'T WORK, EAT THIS HERB
2050 AD         ANTIBIOTICS HAVE SIDE EFFECTS, TAKE THIS HERB

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Tuesday, March 27, 2012

STROKE - A MEDICAL EMERGENCY

Stroke,previously known as cardiovascular accident, is the rapidly developing loss of brain function due to disturbance in blood supply in the brain. This can be due to ischemia caused by blockage hemorrage.
It is a medical emergency  and can lead to permanent neurological damage, complication and lead to death.



Two types of stroke
1.)Ischemic stroke
-80% cases
-due to cerebral infracts
2.)Hemorragic stroke
-due to rupture of artery within brain(intra cerebral hemorrage)
-due to rupture of an aneurysm(eg. subarachnoid hemorrage)

KNOWING STROKES

-first cause of asquired disablity worldwide.
-second cause of death worldwide.


Risk factors
High BP, overweight, high cholesterole, diabetes, lack of exercise

CONSEQUENCES
Brain cell die resulting in damage or loss of neurons.
Physical disablites such as partial loss of movement , hemiplegia, sensory loss, language disorders, visual disorders and even memory loss.

SIGNS AND SYMPTOMS

 





























































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Sunday, March 18, 2012

TASTE THE MEDICINAL VALUES OF GINGER






Traditionally ginger is used to relive cold and stomach pain .
It is rich in inflamation fighting compound such as gingerols,which some experts belive  may hold some promise in fighting some cancer and reducing arthritis pain.
  
People who took ginger capsule daily for 11 days reported 25% less muscle pain when they perform exercises designed to stress muscle(compared to a similiar group of placebo capsules)(recent studies)

Another studies  found that helped to relive pain in the knee.

Acts as stomach soother.

Ginger extracts can help reduce nausea caused by morning sickness or following surgery or chemotherapy.
 But it is less effective for morning sickness.

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Saturday, January 28, 2012

KUPFFER CELLS

                                           MICROSCOPIC SLIDE SHOWING KUPFFER CELLS



1.) WHERE ARE KUPFFER CELLS FOUND?
ANS:- THESE CELLS ARE FOUND IN LVER SPLEEN AND BONE MARROW.


2.) WHAT ARE KUPFFER CELLS?
ANS:- KUPFFER CELLS ARE SPECIALIZED MACROPHAGES LOCATED IN LIVER LINNING WALL OF SINUSOIDS THAT FORM PART OF RETICULO ENDOTHILIAL SYSTEM.

3.) WHAT IS THE FUNCION OF KUPFFER CELLS?
ANS:-

1.) AFTER RUPTURE OF OLD RBC IN SPLEEN KUPFFER CELLS PHAGOCYTOZES THE HEMO GLOBIN.

2.)KUPFFER CELL ACTIVATION IS RESPOSIBLE FOR ALCOHOL INDUCED LIVER DISEASE IN CHRONIC ALCOHOLICS.



HISTORY:
The cells were first observed by Karl Wilhelm von Kupffer in 1876. The scientist called them "sternzellen" (star cells or stellate cells) but thought, falsely, that they were an integral part of the endothelium of the liver blood vessels and that they originated from it. In 1898, after several years of research, Tadeusz Browicz, a Polish scientist, identified them, correctly, as macrophages. 

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Tuesday, November 8, 2011

STANDARD TREATMENT GUIDELINE 2010 PUBLISHED

 CLICK ON THE LINK TO VIEW

http://apps.who.int/medicinedocs/documents/s18015en/s18015en.pdf

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