1.) WHERE ARE KUPFFER CELLS FOUND?
ANS:- THESE CELLS ARE FOUND IN LVER SPLEEN AND BONE MARROW.
2.) WHAT ARE KUPFFER CELLS?
ANS:- KUPFFER CELLS ARE SPECIALIZED MACROPHAGES LOCATED IN LIVER LINNING WALL OF SINUSOIDS THAT FORM PART OF RETICULO ENDOTHILIAL SYSTEM.
3.) WHAT IS THE FUNCION OF KUPFFER CELLS?
ANS:-
1.) AFTER RUPTURE OF OLD RBC IN SPLEEN KUPFFER CELLS PHAGOCYTOZES THE HEMO GLOBIN.
2.)KUPFFER CELL ACTIVATION IS RESPOSIBLE FOR ALCOHOL INDUCED LIVER DISEASE IN CHRONIC ALCOHOLICS.
HISTORY:
The cells were first observed by Karl Wilhelm von Kupffer in 1876. The scientist called them "sternzellen" (star cells or stellate cells) but thought, falsely, that they were an integral part of the endothelium of the liver blood vessels and that they originated from it. In 1898, after several years of research, Tadeusz Browicz, a Polish scientist, identified them, correctly, as macrophages.
